A key gene modulating oxytocin efficacy in autism: genome-wide discovery and verification in randomized controlled trials datasets - PubMed
3 hours ago
- #autism
- #oxytocin
- #genetics
- Oxytocin shows therapeutic potential for autism spectrum disorder (ASD) but responses vary.
- A genome-wide association study (GWAS) identified SNP rs1871303 in the RYR2 gene as linked to oxytocin-induced brain activity improvements.
- Validation in three additional randomized controlled trials confirmed the association between the RYR2 SNP and clinical efficacy based on ADOS scores.
- The RYR2 gene may influence oxytocin response via calcium channel signaling and regulation of oxytocin release.
- This is the first GWAS on oxytocin pharmacogenomics in ASD, highlighting genetic factors in treatment variability.