Tumor-associated CD19+ macrophages induce immunosuppressive microenvironment in hepatocellular carcinoma - PubMed
4 hours ago
- #Immunosuppression
- #Macrophages
- #Hepatocellular Carcinoma
- CD19+ macrophages are identified as a key immunosuppressive subpopulation in hepatocellular carcinoma (HCC).
- These macrophages exhibit high PD-L1 and CD73 levels, reduced phagocytosis, and enhanced mitochondrial oxidation.
- Targeting CD19+ macrophages with anti-CD19 CAR-T cells shows potential in inhibiting HCC tumor growth.
- PAX5 is identified as a driver of mitochondrial biogenesis in CD19+ macrophages, affecting lysosomal function and immune marker accumulation.
- Inhibiting CD73 or mitochondrial oxidation improves the efficacy of immune checkpoint blockade therapy in HCC.