LXR activation in skeletal muscle cells enhances differentiation and promotes protein synthesis - PubMed
3 days ago
- #LXR activation
- #oxysterol signaling
- #muscle regeneration
- LXR activation in skeletal muscle cells enhances differentiation and promotes protein synthesis.
- Cholesterol metabolism plays a critical role in muscle regeneration, with oxysterol-mediated signaling implicated in the process.
- Elevated levels of oxysterols, such as 4β-hydroxycholesterol and 25-hydroxycholesterol, are observed post-muscle injury.
- LXR agonists promote myogenic differentiation in vitro, while LXR inhibition impairs it.
- LXR activation reduces LPS-induced inflammation in myocytes and boosts anabolic signaling via the Akt-mTOR pathway.
- The study highlights the role of cholesterol-derived metabolites in coordinating muscle regeneration, differentiation, and inflammation.