TCR-NF-κB signaling activates the SENP1-NR4A1 axis to fine-tune effector activation of CD8+ T cells - PubMed
4 hours ago
- #SENP1-NR4A1 axis
- #TCR signaling
- #CD8+ T cells
- TCR-NF-κB signaling activates the SENP1-NR4A1 axis to regulate CD8+ T cell activation.
- SENP1 deficiency promotes early TCR-induced CD8+ T cell proliferation and effector gene expression.
- NR4A1 is identified as a deSUMOylation target of SENP1, enhancing its suppressive effect on TCR-induced effector genes.
- Deficiency in the SENP1-NR4A1 axis enhances CD8+ T cell response against L. monocytogenes infection.
- SENP1 integrates TCR-NF-κB signaling with NR4A1 activity to fine-tune immune responses.