Severe thrombocytopenia in antiphospholipid syndrome: a retrospective study of 432 patients - PubMed
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- #retrospective study
- #thrombocytopenia
- #antiphospholipid syndrome
- In a retrospective study of 432 antiphospholipid syndrome (APS) patients, 32.9% developed thrombocytopenia, with 13% experiencing severe cases (<50 G/L).
- Thrombocytopenia in APS was linked to increased thrombotic manifestations, including deep vein thrombosis, coronary thrombosis, and catastrophic APS.
- Patients with thrombocytopenia also had higher rates of pre-eclampsia, skin ulcers, cutaneous necrosis, cardiovascular issues, renal and pulmonary manifestations.
- Severe thrombocytopenia was mainly caused by immune thrombocytopenia and catastrophic APS, with treatments following primary ITP protocols and continued anticoagulation.
- Overall survival was poorer in severe thrombocytopenia patients, indicating an association with a more severe APS phenotype and higher mortality.