Type 2 diabetes subphenotypes are associated with differential outcomes after metabolic and bariatric surgery: An international multicentre retrospective cohort study - PubMed
4 days ago
- #Type 2 diabetes
- #Bariatric surgery
- #Subphenotypes
- Type 2 diabetes (T2D) subphenotypes (MOD, SIRD, SIDD) show differential outcomes after metabolic and bariatric surgery (MBS).
- T2D remission at 2 years was lower in SIDD (36.7%) compared to MOD (79.3%) and SIRD (97.2%).
- SIDD patients had lower BMI, worse beta-cell function, and higher baseline MASH prevalence compared to MOD and SIRD.
- HOMA2-IR was highest in SIRD, indicating severe insulin resistance.
- Total body weight loss (%TWL) was similar across all subphenotypes.
- The study suggests considering metabolic status in treatment decisions to improve patient outcomes.