CLOCK-catalyzed histone H3K37 glutarylation suppresses H3K36 trimethylation pathways in glioblastoma - PubMed
4 hours ago
- #circadian clock
- #glioblastoma
- #histone modification
- CLOCK catalyzes histone H3K37 glutarylation (H3K37glut), a previously undocumented modification.
- H3K37glut blocks SETD2 binding to histone H3, reducing H3K36 trimethylation (H3K36me3) and its downstream pathways.
- In glioblastoma, CLOCK and H3K37glut are abnormally upregulated, correlating with suppressed H3K36me3, tumor progression, and poor patient survival.
- The study reveals a new link between dysregulated circadian CLOCK and decreased H3K36me3 pathways in glioblastoma.