Research trends of tumor-associated macrophages in colorectal cancer: a bibliometric analysis - PubMed
4 hours ago
- #Bibliometric Analysis
- #Tumor-Associated Macrophages
- #Colorectal Cancer
- Colorectal cancer (CRC) is the third most prevalent malignancy and second-highest cause of cancer-related mortality globally.
- Tumor-associated macrophages (TAMs) play a pivotal role in CRC tumorigenesis and disease progression.
- A bibliometric analysis of 2861 publications shows an upward trend in CRC TAMs research since 2018.
- China and the United States are the leading contributors, with Sun Yat-sen University as the most productive institution.
- Key research clusters include CRC biology, TAMs characterization, survival outcomes, disease progression, and metastasis.
- Emerging research directions focus on single-cell RNA sequencing, PD-1/PD-L1 interactions, macrophage polarization, and chemotherapeutic modulation of TAMs.
- Future research is expected to integrate multi-omics, explore the tumor microenvironment, target TAMs, apply AI, and develop personalized treatments.