Nuclear translocation of β-catenin in Wg/Wnt signaling via the IFT-A microtubule-associated complex requires Pasovec/Gid8 proteins - PubMed
4 hours ago
- #Pasovec/Gid8
- #Wg/Wnt signaling
- #β-catenin translocation
- Wg/Wnt signaling is crucial in development, homeostasis, and disease, including cancer.
- β-catenin nuclear translocation is mediated via the IFT-A/Kinesin2 microtubule complex.
- Pasovec/Gid8 proteins are required for nuclear β-catenin localization and interact with IFT140.
- The CRA domain in Pasovec/Gid8 interacts with RanBPM for nuclear localization and affects β-catenin translocation.
- Mutations in the CRA domain can inhibit Wg/Wnt signaling, highlighting Pasovec/Gid8's role as a novel factor.