A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - PubMed
6 days ago
- #lipotoxicity
- #redox imbalance
- #mitochondrial dysfunction
- A genetically encoded bifunctional enzyme, CrGPDH, from Chlamydomonas reinhardtii, mitigates redox imbalance and lipotoxicity.
- CrGPDH operates the Gro3P shunt and glycerol shunt, converting DHAP to Gro3P and Gro3P to glycerol, respectively.
- The enzyme supports cancer cell proliferation under respiratory chain inhibition or hypoxia and aids fibroblasts with mitochondrial dysfunction.
- CrGPDH reduces triglyceride levels in kidney cancer cells and reverses ethanol-induced triglyceride accumulation in mouse liver.
- The tool is promising for treating conditions like mitochondrial diseases and steatosis by alleviating redox imbalance and impaired lipogenesis.
- Authors V.C., X.P., and A.L.Z. are listed as inventors on a patent application related to the enzyme's therapeutic uses.