The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition - PubMed
8 days ago
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- The HUNT study identifies host genetic factors linked to gut microbiota composition.
- Genome-wide association study conducted on 12,652 individuals from the Trøndelag Health Study (HUNT).
- Replication in Nordic cohorts (n = 16,017-21,976) confirmed findings.
- Identified 12 reproducible SNP-species associations across six genomic loci, including known (LCT, ABO) and novel (HLA-DQB1, MUC12, SLC37A2, FUT2) regions.
- Genetic signals associated with gut microbiota functional modules detected at three loci (LCT, ABO, FUT2).
- Host-microbiota associations linked to celiac disease and hemorrhoidal disease pathogenesis.
- Mendelian randomization supports causal effect of body mass index on gut microbiota composition.
- Highlights interplay between host genetics and gut microbiota for human health and disease.