CD5L:p40, a novel heterodimeric regulator of type 2 inflammation - PubMed
3 hours ago
- #CD5L:p40
- #Th17 cells
- #type 2 inflammation
- CD5L:p40 is a novel heterodimer formed by IL-12p40 and CD5Like (CD5L).
- The formation of CD5L:p40 depends on charged residues and occurs in myeloid cells under inflammatory conditions.
- CD5L:p40 induces a unique transcriptome and IL-13 expression from Th17 cells via dual-specificity phosphatase 2.
- A monoclonal antibody targeting CD5L:p40 reduces Th2 responses and airway inflammation.
- The study highlights CD5L:p40's role in type 2 inflammation and its potential as a therapeutic target.