Lactate Metabolism-Immune Regulation-Related Gene Signature in Lower-Grade Gliomas: Prognostic Model Development and Immune Characterization - PubMed
3 hours ago
- #low-grade glioma
- #prognostic model
- #lactate metabolism
- Low-grade gliomas (LGG) show variability in prognosis, with lactate metabolism linked to the tumor immune microenvironment.
- A three-gene prognostic model (VAV3, TNFRSF12A, PLA2G2A) was developed, effectively distinguishing high-risk from low-risk LGG patients.
- High-risk patients had reduced immune infiltration, higher tumor mutation burden (TMB), and worse prognosis but increased sensitivity to certain therapies.
- PLA2G2A was validated as a key gene; its downregulation reduced tumor cell proliferation, migration, and invasion, and reversed epithelial-mesenchymal transition.
- The study provides a prognostic model reflecting metabolic-immune interactions in LGG and suggests PLA2G2A as a potential therapeutic biomarker.