Long-term Effect of Helicobacter pylori Eradication on Risk Factors for Cardiovascular Disease - Is there a Connection? - PubMed

4 hours ago

Cardiovascular disease (CVD) is the leading cause of death worldwide, with chronic inflammation playing a role alongside traditional risk factors.
Helicobacter pylori (H. pylori) infection is proposed as a potential contributor to CVD risk, prompting investigation into long-term effects of its eradication on CVD risk factors.
A study enrolled 72 patients randomized to two 14-day H. pylori eradication regimens, assessing outcomes like insulin resistance (HOMA-IR), lipid profiles, and urinary TMAO levels.
After successful H. pylori eradication, significant reductions were observed in total cholesterol, LDL cholesterol, and small dense lipoprotein particles, with a marginal decrease in TMAO concentrations.
No significant changes were found in body mass index, waist circumference, or HOMA-IR index following eradication.
Conclusions suggest H. pylori eradication leads to favorable changes in lipid metabolism and slight TMAO reduction, indicating H. pylori may influence CVD risk by affecting lipoproteins and inflammation.

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