Heterogeneous associations between molecular subtypes of small cell lung cancer and survival prognosis: a systematic review highlighting knowledge gaps - PubMed
4 days ago
- #Molecular subtypes
- #Survival prognosis
- #Small cell lung cancer
- Small cell lung cancer (SCLC) is a heterogeneous disease with different pathogenic mechanisms.
- Various molecular classification systems have been proposed, but their relationship with survival prognosis remains unclear.
- A systematic review identified eight studies, showing methodological heterogeneity and inconsistent conclusions.
- The inflammatory subtype (SCLC-I) generally shows a survival advantage, while the ASCL1-dominant subtype (SCLC-A) tends to have poorer survival prognosis.
- Future high-quality studies with standardized subtype definitions are needed to validate these findings.
- Emerging multi-omics and integrated spatial analyses have revealed novel subtypes and predictors linked to survival prognosis.