Stepwise topical corticosteroid and dexamethasone rescue strategy enhances baricitinib outcomes in severe alopecia areata: real-life clinical experience - PubMed
3 hours ago
- #alopecia areata
- #baricitinib
- #dexamethasone
- Combining baricitinib with topical corticosteroids and dexamethasone rescue therapy improves outcomes in severe alopecia areata.
- A retrospective study of 19 patients showed 89.5% achieved significant hair regrowth (SALT ≤20) at 52 weeks.
- Pulsed dexamethasone (0.5 mg/kg, twice weekly) was used as rescue therapy for non-responders at 24 weeks.
- This strategy addresses Italian regulatory constraints requiring discontinuation of baricitinib if no significant response within nine months.
- The study highlights the potential of combined therapies for individualized treatment approaches in severe alopecia areata.