Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation - PubMed
3 hours ago
- #H3K27ac
- #Spinal cord injury
- #Microglia
- Persistent histone H3K27 acetylation (H3K27ac) contributes to excessive scar formation after spinal cord injury (SCI).
- Microglial activation post-SCI leads to cholesterol metabolic reprogramming and intracellular cholesterol accumulation.
- H3K27ac regulates cholesterol metabolism gene expression, influencing microglial activation and scar formation.
- Pharmacological inhibition of H3K27ac (using L002) reduces cholesterol accumulation, neuroinflammation, and scar formation.
- SPP1 secretion from activated microglia drives excessive scar formation; H3K27ac inhibition reduces SPP1 levels.
- Targeted modulation of H3K27ac presents a potential therapeutic strategy for improving neural repair post-SCI.