Engineered MSCs enable bone marrow-targeted immunomodulation - PubMed
4 hours ago
- #engineered MSCs
- #immunomodulation
- #bone marrow targeting
- Engineered MSCs target bone marrow for systemic immunomodulation.
- The MSC vector overexpresses Golgi apparatus protein 1 to mimic BM affinity.
- In myelosuppression, it delivers CDK4/6 inhibitors to protect HSPCs from chemotherapy.
- In tumor models, it delivers IL-7 to restore immunity without promoting tumor growth.