Neurological implications of chimeric antigen receptor-T cell therapy - PubMed
6 hours ago
- #CAR-T therapy
- #neurotoxicity
- #neuroimmunology
- CAR-T cell therapies are effective for relapsed or refractory haematological malignancies and are being adapted for severe B-cell mediated autoimmune diseases, including neuroimmunological disorders.
- They offer deep and durable B-cell depletion, potentially leading to long-lasting, treatment-free remission.
- Serious toxicities, particularly neurological complications like immune effector cell-associated neurotoxicity syndrome (ICANS) and movement, cerebellar, cranial nerve, and peripheral nerve syndromes, constrain broader application.
- The review outlines biological principles, emerging experience in neuroimmunology, and distinguishes ICANS from later, more focal toxicities using data from oncology and autoimmune trials.
- As CAR-T cell therapies expand into neuroimmunology, neurologists need to understand their therapeutic promise and risks, requiring multidisciplinary collaboration for safe delivery.