Cystathionine-γ-Lyase/Hydrogen Sulfide Axis Plays a Crucial Role in Promoting the Progression of Cervical Cancer - PubMed
4 days ago
- #cervical cancer
- #hydrogen sulfide
- #CSE
- The study explores the role of the Cystathionine-γ-Lyase (CSE)/Hydrogen Sulfide (H2S) axis in cervical cancer progression.
- CSE is highly expressed in cervical cancer cells (C33A and HeLa) and modulates endogenous H2S levels.
- Knockdown of CSE suppresses proliferation, migration, and invasion of cervical cancer cells.
- CSE-mediated growth involves EMT, mitochondrial apoptosis, pyroptosis, ROS production, and the PI3K/AKT/mTOR pathway.
- CSE knockdown inhibits xenograft tumor growth in vivo, while CSE overexpression promotes it.
- CSE may serve as a potential target for diagnosis, prognosis, and therapy in cervical cancer.