Put your money where your mouth is: Surveillance of antibiotic resistance within the commensal Neisseria - PubMed
3 hours ago
- #Antimicrobial Resistance
- #Pathogenic Evolution
- #Commensal Neisseria
- Commensal Neisseria species serve as reservoirs for antimicrobial resistance, impacting pathogenic relatives like N. gonorrhoeae and N. meningitidis.
- Study analyzed 166 commensal Neisseria isolates, revealing high resistance to azithromycin (76%) and doxycycline (52%), with no resistance to gentamicin.
- Genetic determinants like tetM for doxycycline resistance and MtrD K823E for azithromycin reduced susceptibility were identified.
- PenA 312M mutation linked to elevated MICs for ceftriaxone and cefixime.
- Study highlights the need for continued surveillance of commensal Neisseria to anticipate emerging resistance in pathogenic strains.