Uranium exposure induces osteopenia via mitochondrial dysfunction-driven senescence in bone marrow mesenchymal stem cells - PubMed
3 hours ago
- #Osteopenia
- #Uranium
- #Mitochondrial Dysfunction
- Uranium exposure leads to osteopenia by causing mitochondrial dysfunction and senescence in bone marrow mesenchymal stem cells (BMSCs).
- Long-term uranium accumulation in bones reduces bone formation and increases adipogenesis and osteoclast activity.
- Mitochondrial dysfunction in BMSCs results in senescence-associated secretory phenotype (SASP) secretion, impairing bone homeostasis.
- Nicotinamide mononucleotide (NMN) partially reverses uranium-induced BMSC senescence by improving mitochondrial function.
- Chelating agent TAM-2LI-MAM2 (LNN) reduces uranium levels in bones and restores bone mass and trabecular bone number.