Subtype-Specific Causal Effects of Antidiabetic Drug Targets on Ovarian Cancer: Mendelian Randomization and Colocalization Evidence - PubMed
4 hours ago
- #ovarian cancer
- #Mendelian randomization
- #drug repurposing
- Study explores antidiabetic drug targets as potential therapeutic candidates for ovarian cancer (OC) subtypes.
- Utilized Mendelian randomization and colocalization analyses to assess genetic associations between antidiabetic drug targets and OC risk/survival.
- Identified subtype-specific associations: AKR1A1 (Low grade serous OC), HMGCR/KCNJ11 (clear cell OC), ITGAL/AKR1B1 (mucinous OC), AKR1A1/ITGAL (endometrioid OC).
- DPP4 linked to survival in high-grade serous OC, the most common subtype.
- Findings suggest potential for drug repurposing and personalized treatment strategies based on OC subtypes.