Acid-tolerant injectable bioadhesive for sutureless repair of large gastric perforation - PubMed
6 hours ago
- #bioadhesive
- #sutureless-repair
- #gastric-perforation
- An acid-tolerant injectable hydrogel is developed for sutureless repair of large gastric perforations, overcoming issues with wet adhesion and stability in acidic environments.
- The hydrogel shows rapid in situ gelation, instant wet adhesion, high burst pressure for sealing, and durable adhesion under dynamic in vivo conditions.
- It is tested on a large-scale porcine gastric perforation using a laparoscopic-endoscopic technique, with results showing minimal postoperative adhesion and inflammation, and no interference with transcriptome or microbiome.
- Composed of FDA-approved components, this bioadhesive holds promise for clinical treatment of digestive diseases.