A multi-ancestry genome-wide study of tamoxifen metabolism and breast cancer recurrence - PubMed
4 hours ago
- #breast cancer
- #tamoxifen
- #genome-wide association study
- Study on tamoxifen metabolism and breast cancer recurrence across multiple ancestries.
- CYP2D6 metabolizer status is the primary predictor of steady-state Z-endoxifen levels.
- TCF20 rs932376 A > G has a smaller, independent effect on endoxifen levels.
- Neither CYP2D6 metabolizer status nor TCF20 rs932376 A > G was significantly associated with breast cancer outcomes.
- Findings were validated in independent cohorts.