Impact of pre-vaccination active vitamin D levels on COVID-19 mRNA vaccine-induced immunity in a Japanese cohort - PubMed
3 hours ago
- #Vitamin D
- #Immunity
- #COVID-19 Vaccine
- Pre-vaccination active vitamin D levels (serum 1α, 25-(OH)2 vitamin D) were measured in a Japanese cohort receiving COVID-19 mRNA vaccines (BNT162b2 or mRNA-1273).
- Active vitamin D levels ranged from 33.7 to 99.8 pg/mL, with 45.5% exceeding the Japanese standard limit of 60 pg/mL, but none below the lower reference limit (20 pg/mL).
- Higher active vitamin D levels were negatively associated with anti-S1 IgG and IgM antibody responses (humoral immunity) but positively associated with INF-γ-releasing cell counts (cellular immunity).
- The study suggests that higher active vitamin D levels may benefit vaccine-induced cellular immunity, which is crucial for preventing severe COVID-19 and is robust against viral mutations.
- Limitations include the inability to examine associations with low vitamin D levels, as no subjects had deficient levels in the cohort.