Neutrophil CAPNS1 regulates cardiac inflammation and injury by promoting NETosis in CVB3-induced myocarditis - PubMed
5 days ago
- #NETosis
- #Neutrophil
- #Myocarditis
- Neutrophil CAPNS1 plays a key role in promoting NETosis in CVB3-induced myocarditis.
- CVB3 infection enhances neutrophil recruitment and NETs release, contributing to cardiac inflammation and injury.
- Pharmacological inhibition of NETs formation with Cl-amidine alleviates myocardial inflammation and preserves cardiac function.
- CAPNS1 is significantly upregulated in neutrophils during CVB3 infection and promotes inflammatory responses.
- Conditional knockout of CAPNS1 in neutrophils reduces cardiac inflammation, fibrosis, and injury.
- CAPNS1 promotes NETs formation via calpain-mediated degradation of Nesprin 1.
- Targeting neutrophil CAPNS1 could be a novel therapeutic approach for viral myocarditis.