Optimizing Colorectal Liver Metastasis Ablation through Metabolic Imaging, Margin Assessment, and Biopsy (The OPTABLATE Prospective Trial) - PubMed
3 hours ago
- #PET/CT Imaging
- #Colorectal Liver Metastasis
- #Thermal Ablation
- The OPTABLATE Prospective Trial focuses on optimizing colorectal liver metastasis (CLM) ablation.
- A multimodal approach was used, including metabolic imaging (PET/CT), margin assessment, and biopsy for rapid tissue assessment.
- Immediate reablation was performed if minimal ablation margin (MM) was <5 mm, residual PET-avid tumor was present, or viable tumor (VT) cells were detected.
- 14% of CLMs required immediate reablation, with VT detection being the most common reason.
- MM >5 mm significantly reduced local tumor progression (LTP), with no LTP observed for MM >10 mm.
- The cumulative LTP incidence at 1, 2, and 3 years for successfully ablated CLMs with MM >5 mm was 7%, 12%, and 12%, respectively.
- The study demonstrated improved local tumor control through immediate reablation based on comprehensive ablation zone assessment.