Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1 - PubMed
12 hours ago
- #protein degradation
- #molecular glues
- #drug development
- Molecular glues (MGs) are small-molecule degraders that mediate protein-protein interactions, promoting target protein degradation via the ubiquitin-proteasome system.
- MGs alter surface properties of target proteins or E3 ligases to form ternary complexes, enabling polyubiquitination and degradation.
- Recent advances focus on MGs targeting NEK7, WEE1, CDK2, GSPT1, and VAV1, highlighting their therapeutic potential.
- The review discusses rational design principles, benefits, and limitations of MGs, including challenges in selectivity and efficacy.
- MGs offer novel approaches to disease treatment due to their unique mechanism of action and broad applicability.