Macrophages restrict tumor immune infiltration by controlling collagen topography - PubMed
3 hours ago
- #tumor microenvironment
- #macrophages
- #collagen topography
- Macrophages control immune cell infiltration in tumors by regulating collagen topography.
- Extracellular matrix remodeling during tumorigenesis affects immune cell localization, predicted by fibrillar collagen topography.
- A fibrotic pathway driven by transcription factor 4 (Tcf4) in cancer and stromal cells promotes collagen III deposition, creating intermingled collagen networks that favor T cell and neutrophil infiltration.
- Macrophages inhibit the Tcf4 pathway, playing a structural role in shaping the tumor extracellular matrix.
- Human solid tumor data shows a strong correlation between TCF4, COL3A1, and immune cell signatures (T cells and neutrophils).
- Collagen network topographies are identified as key regulators of tumor-infiltrating immune cells.