Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry - PubMed
2 hours ago
- #prognosis
- #pulmonary hypertension
- #SGLT2 inhibitors
- Group 2 pulmonary hypertension (PH) is caused by left heart disease and remains a challenging condition.
- Elevated pulmonary vascular resistance (PVR >3 Wood units) is significantly associated with worse prognosis in Group 2 PH patients.
- Stratified analyses from two Japanese registries (2012-2016 and 2018-2024) showed lower event-free rates in patients with PVR >3 Wood units.
- SGLT2 inhibitors were associated with improved outcomes in patients with elevated PVR, showing higher event-free rates compared to untreated patients.
- The study suggests that SGLT2 inhibitors may have a therapeutic role in Group 2 PH, warranting further investigation.