Spectrum and functions of ion channels and transporters in osteoclasts - PubMed
4 hours ago
- #osteoclasts
- #bone disorders
- #ion channels
- Osteoclasts are vital for bone resorption and interact with osteoblasts in bone remodeling.
- Ion channels and transporters in the ruffled border and intracellular vesicles coordinate ion and substrate transport, crucial for osteoclast functions.
- ClC-7 and V-ATPase are well-characterized examples, with nearly 90 ion channels and transporters reviewed, categorized into six groups.
- Transporters for hydrogen, chloride, phosphate, and calcium are especially critical for osteoclast function.
- The review includes subcellular localization, substrates, associated diseases, physiological roles, and therapeutic candidates targeting these channels.
- Advances in techniques like transcriptomics suggest greater diversity and unexplored functions of these molecules in osteoclasts.
- Increased focus on their distributions and interactions could reveal new therapeutic targets for bone disorders.