Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk - PubMed
7 hours ago
- #Pancreatic Cancer
- #GWAS
- #eQTL
- Pancreatic cancer is a highly lethal malignancy with unresolved genetic links from GWAS.
- A genome-wide regulatory map was created using eQTL analysis of 482 pancreatic tissues.
- Integration with GWAS meta-analysis identified 82 significant variants and 15 target genes for pancreatic cancer risk.
- The variant rs11102484 was validated in an independent cohort, showing a protective effect against pancreatic cancer.
- Functional assays revealed that the G allele of rs11102484 impairs ZNF263 binding, increasing ST7L expression.
- Elevated ST7L suppresses pancreatic cancer cell proliferation by dampening AKT/β-catenin signaling.
- The study advances understanding of genetic regulation in pancreatic cancer risk and biology.