Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity - PubMed
7 hours ago
- #immunometabolism
- #tumor immunity
- #cancer research
- The article introduces the 'immunometabolic gatekeeping' framework, explaining how tissue metabolism influences tumor immunity.
- It addresses why immune infiltration does not always lead to tumor control, highlighting variability across different tissues.
- High-flux tissues experience metabolic stress that impairs immune surveillance, allowing tumors to grow despite immune presence.
- This framework helps explain several cancer paradoxes, including variability in T cell prognosis and tumor tropisms in hereditary and pediatric cases.
- It also accounts for sex-biased tumor incidence and differences in cancer resistance among species.
- The authors suggest that considering metabolism can inform strategies for cancer prevention and immunotherapy.