A novel dual elastography-based model for screening high-risk varices in hepatitis B virus-related cirrhosis - PubMed
a day ago
- #non-invasive test
- #cirrhosis
- #hepatitis B
- A novel dual elastography-based model (DELU) was developed for screening high-risk varices (HRVs) in hepatitis B virus (HBV)-related cirrhosis.
- DELU incorporates six variables: platelet count (PLT), alanine aminotransferase (ALT), ascites, portal vein thrombosis (PVT), inverse difference moment (IDM), and liver stiffness (liver Vs).
- The model demonstrated superior diagnostic accuracy with AUROCs of 0.822 (training) and 0.779 (validation), outperforming other non-invasive tests (NITs) like RESIST-HCV and Baveno VI criteria.
- DELU showed the highest spared-EGD rates (20.7% training; 11.1% validation) and maintained robust performance across various subgroups, including Child-Pugh B/C and A patients.
- The study concluded that DELU is a reliable and safe non-invasive tool for excluding HRVs in HBV-related cirrhosis, with significant endoscopy-sparing potential.
- RESIST-HCV may serve as a safe alternative when elastography is unavailable.