Free water changes and their correlations with multimodal biomarkers in frontotemporal dementia - PubMed
4 hours ago
- #neurodegeneration
- #frontotemporal dementia
- #glymphatic system
- Study examines free water (FW) changes in behavioral variant frontotemporal dementia (bvFTD).
- 112 bvFTD patients and 103 normal controls were evaluated for FW levels in the whole brain and specific white matter tracts.
- BvFTD patients showed elevated FW in the whole brain and regional white matter tracts, particularly in the uncinate fasciculus and cingulum hippocampus.
- FW correlated with perivascular spaces (PVSs), DTI-ALPS index, clinical scales, gray matter volume, and glucose metabolism.
- FW also correlated with plasma glial fibrillary acidic protein and total tau levels.
- Mediation analyses revealed FW mediates the association between PVS and ALPS, and brain neurodegeneration mediates the association between FW and clinical scores.
- Elevated FW in bvFTD is linked to glymphatic dysfunction and neurodegeneration.