Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials - PubMed
8 days ago
- #postoperative care
- #delirium prevention
- #geriatric anesthesia
- The study aimed to identify effective drug interventions for preventing delirium in adults over 60 after surgery.
- A systematic review and network meta-analysis of 158 randomized controlled trials with 41,084 participants was conducted.
- Key effective drugs included Dexmedetomidine, corticosteroids, melatonin receptor agonists, parecoxib, olanzapine, and intranasal insulin.
- Corticosteroids were noted to reduce the severity of delirium.
- Most interventions did not affect length of stay, mortality, cognition, or quality of life.
- Dexmedetomidine was associated with higher rates of hypotension and bradycardia but reduced postoperative nausea and vomiting.
- The study highlighted issues with trial registration practices and the adoption of core outcome sets in research on delirium prevention.