Two decades of hepatitis E in solid organ transplantation: A retrospective monocentric analysis - PubMed
4 hours ago
- #hepatitis E
- #ribavirin treatment
- #solid organ transplantation
- Study analyzed 6452 solid organ transplant (SOT) patients from 2001-2024, finding HEV infection in 228 (3.53%).
- Chronic hepatitis developed in 65.1% of infected patients within 3 months; tacrolimus use increased risk, while mycophenolic acid was protective.
- Ribavirin treatment achieved 91.5% sustained virological response when continued until full HEV RNA clearance in serum and stool.
- Extrahepatic manifestations included neurological (2.2%) and glomerular diseases (3.9%), often resolving after viral clearance.
- Screening for HEV is recommended in SOT patients with elevated liver enzymes to manage chronicity and complications.