Gamma delta T cells promote intestinal fibrosis via an interleukin-17A-induced transforming growth factor-beta signaling pathway in fibroblasts - PubMed
4 hours ago
- #Intestinal fibrosis
- #Crohn's disease
- #Gamma delta T cells
- Gamma delta T (γδ T) cells promote intestinal fibrosis in Crohn's disease (CD).
- A mouse model of CD-associated fibrosis was created using TNBS in ethanol.
- Interventions with anti-IL-17A or anti-γδ TCR antibodies reduced fibrosis.
- In vitro, co-culture of γδ T cells and fibroblasts increased fibrosis markers.
- The TGF-β/Smad pathway was activated in fibrosis and inhibited by antibodies.
- Targeting γδ T cells or IL-17A may be a therapeutic strategy for CD fibrosis.