Mechanisms of the JNK/p38 MAPK signaling pathway in drug resistance in ovarian cancer - PubMed
5 days ago
- #MAPK signaling
- #ovarian cancer
- #drug resistance
- Ovarian cancer (OC) is the most lethal malignancy in the female reproductive system, with chemotherapy drug resistance being a major cause of treatment failure.
- The JNK/p38 MAPK signaling pathway plays a dual role in OC chemoresistance, influencing key biological processes like apoptosis, autophagy, DNA damage response, tumor microenvironment (TME), and drug efflux.
- This pathway interacts with other signaling pathways such as PI3K/AKT and NF-κB, contributing to treatment resistance.
- Targeting the JNK/p38 MAPK pathway shows promise in reversing chemoresistance, with inhibitors and natural compounds demonstrating potential in preclinical studies.
- Regulating JNK/p38 MAPK could transform chemotherapy resistance from a terminal obstacle into a manageable challenge, improving patient survival and quality of life.