Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection - PubMed
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- #macrophage-glia interactions
- #enteric neurons
- #West Nile virus
- Macrophage-glia interactions protect enteric neurons during West Nile virus (WNV) infection.
- WNV causes gastrointestinal (GI) dysmotility in mice by damaging enteric neurons via T cell-mediated cytolysis.
- Resident muscularis macrophages upregulate antiviral, proinflammatory, and immunomodulatory genes in response to WNV infection.
- Depletion of macrophages reshapes glial response, increasing T cell and neutrophil chemoattractants, worsening neuronal injury.
- Macrophages regulate glia-driven inflammation, preventing excessive immune-mediated damage to enteric neurons.