Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial - PubMed
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- #healthy aging
- #multivitamin supplementation
- #metabolomics
- The COSMOS trial tested daily multivitamin-mineral (MVM) supplementation in older U.S. adults over two years.
- MVM supplementation increased levels of docosahexaenoic acid and omega-3 fatty acids and slowed the rise in creatinine.
- MVM reduced metabolomic risk scores for 16 chronic diseases, including cardiovascular events, dementia, and certain cancers.
- Effects on metabolites and risk scores were nominally significant but did not survive multiple-testing correction.
- MVM showed a non-significant trend toward decreasing metabolomic aging clocks by approximately 0.5 to 1 year.
- The study provides preliminary evidence of modest improvements in metabolomic profiles with MVM use in older adults.