Treatment-free remission in MS: long-term disease control with cladribine tablets - PubMed
3 hours ago
- #Cladribine
- #Multiple Sclerosis
- #Treatment-free Remission
- Oral cladribine is a highly effective pulsed selective immune reconstitution therapy (SIRT) for relapsing multiple sclerosis (RMS).
- Cladribine tablets allow extended treatment-free periods after brief medication exposure, with long-term real-world data showing stable disease control in many patients beyond year 4.
- The unique mode of action involves rapid lymphocyte repopulation with different subset dynamics and sustained reduction of memory B cells.
- Retreatment with cladribine tablets is effective and tolerable for mild recurring disease activity.
- Cladribine tablets enable treatment-free remission over 6 years as an achievable goal for a substantial proportion of RMS patients.