Aberrant immune regulation and enrichment of stem-like CD8 + T cells in the pancreatic lymph node during type 1 diabetes development - PubMed
4 hours ago
- #pancreatic lymph node
- #CD8 T cells
- #type 1 diabetes
- Enriched T stem-cell memory (TSCM)-like CD8+ T cells found in pancreatic lymph nodes (pLNs) during type 1 diabetes (T1D).
- scRNAseq shows elevated inflammatory cytokine genes and reduced exhaustion markers in CD8+ T cells from T1D pLNs.
- IL-15 signaling identified as a key driver of aberrant CD8+ T cell phenotypes in T1D development.
- Shared effector CD8+ T cell clones between pLNs and pancreas, with increased terminal effector signatures in the pancreas.
- Differential localization of TCF1+ and TOX+ T cells near pancreatic islets, indicating mixed activation/exhaustion states.