Female Sexual Dysfunction Induced by Second-Generation Antipsychotic Drugs-A Disproportionality Analysis Based on the FAERS Database - PubMed
4 hours ago
- #sexual dysfunction
- #antipsychotics
- #pharmacovigilance
- Second-generation antipsychotics (SGAs) are linked to female sexual dysfunction, an often underrecognized side effect.
- The study analyzed FAERS data from 2004 to 2023, focusing on nine SGAs including aripiprazole, quetiapine, and olanzapine.
- A total of 11,786 reports were identified, with women aged 19-41 years being the largest subgroup (40.6%).
- Aripiprazole was strongly associated with compulsive sexual behavior and hypersexuality.
- Risperidone and paliperidone were linked to decreased libido and anorgasmia.
- Prolactin-elevating drugs were associated with older age, intramuscular use, and more serious outcomes.
- The study emphasizes the need for clinicians to consider sexual side effects when prescribing SGAs and to monitor patients accordingly.