Multifaceted roles for persulfide species in redox chemical biology - PubMed
4 hours ago
- #Reactive sulfur species
- #Redox signaling
- #Persulfide therapeutics
- Reactive sulfur species (RSS) are important bioactive agents with versatile roles in biology.
- Persulfide formation on cysteine residues plays a key role in redox signaling and metabolic pathways.
- RSS have both pro-oxidant and antioxidant capacities, influencing stress responses and disease pathophysiology.
- RSS are implicated in cardiovascular diseases, neurodegenerative diseases, and cancer.
- New chemical tools and detection methods have expanded understanding of RSS functions.
- Pharmacological and genetic approaches to adjust persulfide levels are potential therapeutic interventions.
- Critical discussion on detection methods and recommendations for advancing persulfide-based therapies is provided.