Dynamic reprogramming of the tumor immune network via multicycle checkpoint degradation for cancer immunotherapy - PubMed
4 hours ago
- #checkpoint degradation
- #tumor immune microenvironment
- #cancer immunotherapy
- The RECYC platform targets immune checkpoints in the tumor immune microenvironment (TIME) for degradation.
- RECYC uses a CI-M6PR-targeting aptamer and a pH-responsive protein-binding peptide to drive recycling and sustained checkpoint clearance.
- It effectively eliminates PD-L1 expression from tumor cells and tumor-associated myeloid cells (macrophages, neutrophils, dendritic cells).
- RECYC converts an immunosuppressive TIME to an immunostimulatory state, enhancing CD8+ T cell response and repolarizing myeloid cells.
- Shows superior anti-tumor effects in both immune-cold and immune-hot murine cancer models compared to PD-L1 blockade.
- Offers a strategy for broad checkpoint clearance and durable immunotherapy responses by reprogramming the tumor-immune network.