Mechanistic Research and Therapeutic Prospects of Alternative Splicing in Neurodegenerative Diseases - PubMed
3 hours ago
- #Neurodegenerative Diseases
- #Therapeutic Targets
- #Alternative Splicing
- Alternative splicing is a key post-transcriptional process that enhances protein diversity and is vital for nervous system function.
- Dysregulation of alternative splicing is linked to neurodegenerative diseases, such as Alzheimer's (via tau and amyloid precursor protein variants), Parkinson's (via SNCA and PARK2 variants), and ALS/frontotemporal dementia (via STMN2).
- Splicing is regulated by trans-acting factors like SR proteins and hnRNPs, but their complex networks in neurons are not fully understood, limiting therapeutic development.
- This review covers splicing mechanisms in neurodegeneration, recent therapeutic advances, and biomarkers, offering insights for future treatments.