Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum - PubMed
3 hours ago
- #social memory
- #neuroscience
- #GABAergic neurons
- Two distinct types of GABAergic neurons in the lateral septum (LS) regulate social memory bidirectionally.
- Somatostatin (SST) expressing neurons enhance social memory acquisition, while calbindin 1 (CB) expressing neurons inhibit it.
- Optogenetic manipulation of SST+ neurons affects theta oscillations, which correlates with their impact on social memory.
- SST+ neurons in the dorsal LS (dLS) and CB+ neurons in the ventral LS (vLS) receive stronger inputs from different parts of the hippocampus (vCA1d and vCA1v, respectively).
- The vCA1d→SST+-dLS→lateral hypothalamic area (LHA) circuit promotes social memory acquisition.
- The vCA1v→CB+-vLS→anterior hypothalamic nucleus (AHN) pathway suppresses social memory.
- The study provides insights into the neural circuits underlying dynamic regulation of social memory in male mice.