Global to local burdens, inequalities, and achievable frontiers of child and adolescent malignant neoplasm of bone and articular cartilage across 953 countries and sublocations, 1980-2040, with deep l
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- Global study on malignant neoplasm of bone and articular cartilage (MNBAC) in children and adolescents from 1980-2040.
- Prevalence and incidence rates increased by 14.7% and 14.3% respectively from 1990-2021, with 139,154 cases by 2021.
- Males and adolescents aged 15-19 years are disproportionately affected.
- Mortality declined globally but increased in low-middle SDI regions, with 87.3% of countries and 93.8% of subnational locations showing rising mortality.
- YLD/YLL ratio increased, indicating a shift from fatal to non-fatal burdens, mainly in high and high-middle SDI regions.
- By 2021, 94.1% of countries and 81.4% of subnational locations failed to meet achievable frontiers.
- Forecasts predict rising incidence and stagnant mortality by 2040, with widening disparities.
- 30% of top 100 high-prevalence subnational locations by 2040 will likely be in Sub-Saharan Africa.
- Mortality rates to remain highest in low SDI regions, especially Eastern Sub-Saharan Africa.
- Targeted healthcare policies and increased investment are needed to address the growing burden.